Manager, R&D Antibody Discovery

Job description

Work Schedule Standard (Mon-Fri) Environmental Conditions Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.) Job Description About the company Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with annual revenue of approximately $44 billion. Our Mission is to enable our customers to make the world healthier, cleaner, and safer. Whether our customers are accelerating life sciences research, solving analytical challenges, growing efficiency in their laboratories, improving patient health through diagnostics, or developing and manufacturing life-changing therapies, we are here to support them. Our distributed team delivers an outstanding combination of innovative technologies, purchasing convenience, and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon, and PPD. Our Innovative Laboratory technologies & Services makes it easier for customers.   About Team: Antibody team The antibody team is involved in development and engineering of antibodies, with a deep focus on reagent quality and specificity. The core activities of team include design, development, purification, conjugation and testing of antibodies in a variety of immunoassay applications using current tools and technologies. The goal of the program is sophisticated product development and creation of product specific information to promote research use.   Role & Responsibilities Role: To be an integral part of an antibody development team with a focus on performance and specificity using innovative molecular, protein, and cell biology methods. The successful candidate will be joining the Bangalore R&D leadership team in developing products and solutions for discovery, validation and characterization of antibodies for the Thermo Fisher Scientific product portfolio. The candidate should be well versed with recombinant antibody development using state-of-art technology. This position involves people management, multi-disciplinary internal, external and cross function collaboration to drive execution of R&D projects. Responsibilities: ·        Contribute in a fast- paced environment towards antibody development & validation ·        R&D Manager role in new antibody development projects using single B cell sorting or phage display technology, with vast experience in experimental planning and execution to meet the program schedule ·        Manage a team of scientists in matrix style operation, provide technical and operational supervision. ·        Good scientific writing skills, establishing technical protocols for effective transfer to operation teams. ·        Mentoring and training junior scientists in research, designing and experimental execution, interpreting data and data presentation to the stakeholders ·        Good documentation practice is a must to maintain data integrity and accuracy. ·        Delivering high quality results according to project schedule in support of product commercialization from concept to launch including early feasibility, development and validation phases. ·        Support the manufacturing team for technical support and quality by providing technical guidance. Candidate Requirement: Education & Experience levels: Applicants should have a Ph.D in Biotechnology/Life Sciences or related subject area with over 10 years relevant experience. Minimum 3-4 years of industrial experience and people management experience is required. Nature of experience: ·        Experience with antibody development and engineering including hybridoma, single B cell, phage or yeast display and other recombinant antibody platforms ·        Experience in applying scientific principles of antibody development with emerging technologies such as deep sequencing or mining of antibody repertoires using NGS (next generation sequencing), phage or cell display, affinity maturation etc. ·        Understanding of current technology trends and use of AI/ML in antibodies or protein design is an advantage ·        Prior work in single cell molecular workflows is desirable. ·        Proficiency in high-throughput molecular cloning methods ·        Thorough in biochemical and biophysical workflows such as recombinant protein expression and purification, antibody characterization using SPR or BLI. ·        Working knowledge of immunoassay technologies like sandwich ELISA, bead based immunoassays and proximity ligation assays ·        Broad knowledge and experience in molecular biology, protein design, engineering, purification, and conjugation ·        Ability to provide technical trouble shooting to resolve scientific problems. ·        <